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First PublishedTitleAuthor(s)Type
17-Jun-2011A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.Taylor, DM; Balabadra, U; Xiang, Z; Woodman, B; Meade, S; Amore, A; Maxwell, MM; Reeves, S; Bates, GP; Luthi-Carter, R; Lowden, PA; Kazantsev, AGJournal Article
1-Aug-2007Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Kuhn, A; Goldstein, DR; Hodges, A; Strand, AD; Sengstag, T; Kooperberg, C; Becanovic, K; Pouladi, MA; Sathasivam, K; Cha, JH; Hannan, AJ; Hayden, MR; Leavitt, BR; Dunnett, SB; Ferrante, RJ; Albin, R; Shelbourne, P; Delorenzi, M; Augood, SJ; Faull, RL; Olson, JM; Bates, GP; Jones, L; Luthi-Carter, RJournal Article
Aug-2010Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.Benn, CL; Luthi-Carter, R; Kuhn, A; Sadri-Vakili, G; Blankson, KL; Dalai, SC; Goldstein, DR; Spires, TL; Pritchard, J; Olson, JM; van Dellen A; Hannan, AJ; Cha, JHJournal Article
Jan-2012Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.Jiang, M; Wang, J; Fu, J; Du, L; Jeong, H; West, T; Xiang, L; Peng, Q; Hou, Z; Cai, H; Seredenina, T; Arbez, N; Zhu, S; Sommers, K; Qian, J; Zhang, J; Mori, S; Yang, XW; Tamashiro, KL; Aja, S; Moran, TH; Luthi-Carter, R; Martin, B; Maudsley, S; Mattson, MP; Cichewicz, RH; Ross, CA; Holtzman, DM; Krainc, D; Duan, WJournal Article
Sep-2010Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.Zucker, B; Kama, JA; Kuhn, A; Thu, D; Orlando, LR; Dunah, AW; Gokce, O; Taylor, DM; Lambeck, J; Friedrich, B; Lindenberg, KS; Faull, RL; Weiller, C; Young, AB; Luthi-Carter, RJournal Article
Jun-2011Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease.Tang, B; Seredenina, T; Coppola, G; Kuhn, A; Geschwind, DH; Luthi-Carter, R; Thomas, EAJournal Article
15-Mar-2011In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Thomas, EA; Coppola, G; Tang, B; Kuhn, A; Kim, S; Geschwind, DH; Brown, TB; Luthi-Carter, R; Ehrlich, MEJournal Article